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Genomic Detectives Crack the Case of the Missing Heritability

By Guest PostFebruary 23, 2013Scienceantibiotics, bert vogelstein, caffeine, case, caused by mutation, common dna spelling, crohns disease, dna code, dna variation, drugs, environmental factors, eye color, family traits, genetic causes, genetic code, genetic factors, genomic detectives, gwas, ian ehrenreich, joshua bloom, leonid kruglyak, metal compounds, missing heritability, missing heritability problem, model organism, patterns of inheritance, physical characteristic, princeton university, regions of dna, researcher, risk, risk of diseases, schizophrenia, southern california, thuy lan lite, type 2 diabetes, university, variation, wesley loo, yeast cell

Despite years of research, the genetic factors behind many human diseases and characteristics remain unknown. The inability to find the complete genetic causes of family traits such as height or the risk of type 2 diabetes has been called the “missing heritability” problem.

A new study by Princeton University researchers, however, suggests that missing heritability may not be missing after all — at least not in yeast cells, which the researchers used as a model for studying the problem. Published in the journal Nature, the results suggest that heritability in humans may be hidden due only to the limitations of modern research tools, but could be discovered if scientists know where (and how) to look. (more…)

Pesticides and Parkinson’s: UCLA Researchers Uncover Further Proof of a Link

By Guest PostJanuary 11, 2013Environment, Healthaaron lulla, aldehyde dehydrogenase, aldh, aldh activity, arthur g fitzmaurice, benomyl, benomyl exposure, brain malformations, california, carcinogenesis, case, cellular event, central valley, common chemical, culprit, damage, degeneration of neurons, disease, dopal, dopaminergic neurons, drifting particles, environmental protection agency, enzyme, genetic variations, hoa a lam, jeff bronstein, link, lisa barnhill, liver tumors, maneb, mid brain, molecular tweezers, neurologist, neuron, neurotransmitter, nigel t maidment, paraquat, parkinson's, parkinsons symptoms, pesticide, progression of disease, protein, reproductive effect, rigidity, slowed movement, speech, spray, substantia nigra, therapeutic drugs, toxicological effect, toxin, tremor, ucla, ziram, α synuclein

Study suggests potential new target in fight against debilitating disease

For several years, neurologists at UCLA have been building a case that a link exists between pesticides and Parkinson’s disease. To date, paraquat, maneb and ziram — common chemicals sprayed in California’s Central Valley and elsewhere — have been tied to increases in the disease, not only among farmworkers but in individuals who simply lived or worked near fields and likely inhaled drifting particles.

Now, UCLA researchers have discovered a link between Parkinson’s and another pesticide, benomyl, whose toxicological effects still linger some 10 years after the chemical was banned by the U.S. Environmental Protection Agency. (more…)

Close Up Look at a Microbial Vaccination Program

By Guest PostOctober 3, 2011Health, Sciencebacterium, berkeley lab, blake wiedenheft, casa, casb, case, cells, clustered regularly interspaced short palindromic repea, complex of proteins, crispr, cryo electron microscopy, e coli, escherichia coli, eva nogales, gabriel lander, human pathogens, immune system, infections by bacteria, invading pathogens, jennifer doudna, john van der oost, kaihong zhou, microbe, microbial, microbial immune systems, microbiome, perturbations, protein complex called cascade, seahorse, short interfering rnas, sirnas, symbioses, toxins, unit of dna, viruses

*Berkeley Lab Researchers Resolve Sub-nanometer Structure of Cascade, an Ally for Human Immune System*

A complex of proteins in the bacterium E.coli that plays a critical role in defending the microbe from viruses and other invaders has been discovered to have the shape of a seahorse by researchers with the U.S Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). This discovery holds far more implications for your own health than you might think.

In its never-ending battle to protect you from infections by bacteria, viruses, toxins and other invasive elements, your immune system has an important ally – many allies in fact. By the time you reach adulthood, some 90-percent of the cells in your body are microbial. These microbes – collectively known as the microbiome – play a critical role in preserving the health of their human host. (more…)

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Genomic Detectives Crack the Case of the Missing Heritability

Pesticides and Parkinson’s: UCLA Researchers Uncover Further Proof of a Link

Close Up Look at a Microbial Vaccination Program