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New Information on the Waste-Disposal Units of Living Cells

By Guest PostJanuary 15, 2012Scienceandreas martin, base, berkeley lab, biochemical processes, cellular proteins, charlene bashore, degradation, degrade, diseases, dna repair, eric estrin, eva nogales, gabriel lander, heterologous expression system, human cell, immune defense system, irreversible, kiss of death, lid, living cells, mary matyskiela, non atpase proteins, polypeptide, proteasome machinery, proteasome regulatory particle, proteasomes, protein functions, protein machines, regulatory particle, subnanometer scale, transcription, treatment of cancer, ubiquitin, university of california, waste disposal, yeast

*Berkeley Researchers Provide Detailed Look at Proteasome’s Regulatory Particle*

Important new information on one of the most critical protein machines in living cells has been reported by a team of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. The researchers have provided the most detailed look ever at the “regulatory particle” used by the protein machines known as proteasomes to identify and degrade proteins that have been marked for destruction. The activities controlled by this regulatory particle are critical to the quality control of cellular proteins, as well as a broad range of vital biochemical processes, including transcription, DNA repair and the immune defense system. (more…)

Making Blood-Sucking Deadly for Mosquitoes

By Guest PostJuly 17, 2011Scienceaedes aegypti, biochemical processes, blood feeding, blood meal, cellular process, coatomer protein 1, copi, copi system, dengue fever, dengue hemorrhagic fever, dengue viruses, digestive enzymes, egg production cycle, jun isoe, molecular process cells, mosquitoes, protein complex, proteins, rnai, roger miesfeld, secretion of enzymes, sub tropical, tablespoons of sugar, the university of arizona, toolbox, tropical regions of africa, vesicle transport, warm blooded animals

*Inhibiting a molecular process cells use to direct proteins to their proper destinations causes more than 90 percent of affected mosquitoes to die within 48 hours of blood feeding, a UA team of biochemists found.*

Mosquitoes die soon after a blood meal if certain protein components are experimentally disrupted, a team of biochemists at the University of Arizona has discovered.

The approach could be used as an additional strategy in the worldwide effort to curb mosquito-borne diseases like dengue fever, yellow fever and malaria. (more…)

Tag Archives: biochemical processes

New Information on the Waste-Disposal Units of Living Cells

Making Blood-Sucking Deadly for Mosquitoes