Drugs introduced more than a decade ago that target mutations in a protein known as the epidermal growth factor receptor (EGFR) held the promise of personalized treatments for a common form of non-small cell lung cancer. But most patients quickly develop resistance to these drugs and are left with few or no treatment options, because it has been very difficult to design new drugs that act selectively upon the drug-resistant form. (more…)
Catalysis may initiate almost all modern industrial manufacturing processes, but catalytic activity on solid surfaces is poorly understood. This is especially true for the cellulase enzymes used to release fermentable sugars from cellulosic biomass for the production of advanced biofuels. Now, researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) through support from the Energy Biosciences Institute (EBI) have literally shed new light on cellulase catalysis.
Using an ultrahigh-precision visible light microscopy technique called PALM – for Photo-Activated Localization Microscopy – the researchers have found a way to improve the collective catalytic activity of enzyme cocktails that can boost the yields of sugars for making fuels. Increasing the sugar yields from cellulosic biomass to help bring down biofuel production costs is essential for the widespread commercial adoption of these fuels. (more…)
Cheating is a behavior not limited to humans, animals and plants. Even microscopically small, single-celled algae do it, a team of UA researchers has discovered.
Humans do it, chimpanzees do it, cuckoos do it – cheating to score a free ride is a well-documented behavior by many animals, even plants. But microscopically small, single-celled algae? Yes, they do it too, biologists with the University of Arizona’s department of ecology and evolutionary biology have discovered.
“There are cheaters out there that we didn’t know of,” said William Driscoll, lead author of a research report on the topic who studied an environmentally devastating toxic alga that is invading U.S. waters as part of his doctoral research in the lab of Jeremiah Hackett, an assistant professor of ecology and evolutionary biology. (more…)
Using Fossil Pollen to Augment Historical Records
Ancient pollen and charcoal preserved in deeply buried sediments in Egypt’s Nile Delta document the region’s ancient droughts and fires, including a huge drought 4,200 years ago associated with the demise of Egypt’s Old Kingdom, the era known as the pyramid-building time.
“Humans have a long history of having to deal with climate change,” said Christopher Bernhardt, a researcher with the U.S. Geological Survey. “Along with other research, this study geologically reveals that the evolution of societies is sometimes tied to climate variability at all scales – whether decadal or millennial.” (more…)
EAST LANSING, Mich. — The secret to the deadly 2011 E. coli outbreak in Germany has been decoded, thanks to research conducted at Michigan State University.
The deadliest E. coli outbreak ever, which caused 54 deaths and sickened more than 3,800 people, was traced to a particularly virulent strain that researchers had never seen in an outbreak before. In the current issue of the academic journal PLoS ONE, a team of researchers led by Shannon Manning, MSU molecular biologist and epidemiologist, suggests a way to potentially tame the killer bacteria. (more…)
