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Biosensor Illuminates Compounds to Aid Fight Against TB

By Guest PostMay 16, 2012Scienceagbioresearc, antibiotics, biosensor, chris wilson, chronic infection, chronic tb, drug resistant, drug therapy, environmental oxygen, global health, glows green, grand challenges explorations, immunization, infection, nutrition, oxygen sensing system, robert abramovitch, synthetic biosensor, tb, tb bacterium, treatment, tuberculosis, tuberculosis epidemic

EAST LANSING, Mich. — For his work on developing new treatments for tuberculosis, a Michigan State University researcher has been named a Grand Challenges Explorations winner, an initiative funded by the Bill & Melinda Gates Foundation.

Robert Abramovitch of MSU’s Department of Microbiology and Molecular Genetics is using a synthetic biosensor that glows green in response to conditions that mimic human tuberculosis infection. He will screen for compounds that target chronic TB infection and may help shorten therapy or treat multidrug-resistant TB, which does not respond well to existing antibiotics. (more…)

Treatment For TB Can Be Guided By Patients’ Genetics

By Guest PostFebruary 11, 2012Scienceanti-inflammatory, charles serhan, corticosteroids, david tobin, dexamethasone therapy, duke university, francisco roca, gene, gene variant, genetic sequence, goldilocks effect, guy thwaites, harvard university, heterozygous advantage, human genetics, hyperinflammation, infection, inflammation, inflammatory response, lalita ramakrishnan, leukotriene b4, lipoxins, lta4h, mary claire king, mutation, oxford university, patient, pro inflammatory, seattle, substance, tb, tb like infection, tb meningitis, tuberculosis, tuberculosis treatment, university of washington, Vietnam, zebrafish

A gene that influences the inflammatory response to infection may also predict the effectiveness of drug treatment for a deadly form of tuberculosis.

An international collaboration between researchers at the University of Washington in Seattle, Duke University, Harvard University, the Oxford University Clinical Research Unit in Vietnam and Kings College London reported these findings Feb. 3 in the journal Cell. (more…)

Will the Next Bill Gates Please Step Up: Young Entrepreneurs Meet Microsoft’s Founder

By Guest PostJanuary 30, 2012Technologyaids, Bill Gates, bing maps, brad smith, croatia, davos, dominik tomicevic, dreamspark program, ecuador, gerardo francisco perez layedra, horizon, imagine cup, jason wakizaka, jordan, kinect, malaria, melinda gates, microsoft chairman, mohammad azzam, ngo, project horizon, skillbox, social entrepreneur, student technology, switzerland, team falcondev, team kidnect, team lifelens, team oasys, tuberculosis, vision center, windows phone, world economic forum

*Students from around the world talked with Microsoft Chairman Bill Gates and Executive Vice President Brad Smith on Friday about removing obstacles that keep young people from starting their own businesses and nonprofits.*

Davos, Switzerland — Jan. 30, 2012 — When the world’s policymakers descend on Davos, Switzerland, for the World Economic Forum Annual Meeting, Bill Gates can usually get their attention.

This year, in between discussing food sustainability and announcing a US$750 million donation to fight AIDS, malaria, and tuberculosis, Gates turned his attention to a few students who hope to make a similarly outsized humanitarian mark on the world. (more…)

When It Comes To Charitable Giving, People Respond To Their Immediate Emotions, Cu Study Says

By Guest PostOctober 7, 2011Culture, General2010 earthquake in haiti, diseases, doctors without borders, dresden university of technology, famine and genocide in africa, Germany, giving money to humanitarian crises, haitian earthquake, immediate emotions, laura johnson graham, leaf van boven, malnutrition, michaela huber, peter mcgraw, red cross, tragic events, tuberculosis, united states, university of colorado boulder

When considering giving money to humanitarian crises people often donate in response to events that grab their immediate emotions, according to a recent study by researchers at the University of Colorado Boulder and Dresden University of Technology in Germany.

“The question we wanted to answer with our study is what is the impact of people’s emotions on their decisions to make charitable donations,” said CU-Boulder psychology Professor Leaf Van Boven, who co-authored the study. “We demonstrated that people act on what is immediately emotionally arousing to them. In other words, they respond to what makes them upset in the here and now.” (more…)

Yale Researchers Identify Four Key Weapons in Immune System’s Arsenal

By Guest PostMay 7, 2011Health4 key weapons, bacterial infections, deliver antimicrobial enzymes, food-borne bacteria, gastrointestinal illness, gtpases, hepatitis c, immune-compromised, interferon therapy, john d. macmicking, macrophage, marshal immune system, microbial pathogenesis, mimic, noxious chemicals, pathogens, pulmonary diseases, tuberculosis, variety of pathogens, winchester fund and cancer research institute, yale university

Yale University researchers have identified four unique host defense proteins among thousands that seem to play a crucial role in mobilizing the immune system’s response to bacterial infections, they report in the May 6 issue of the journal Science.

The findings suggest it may be possible to find new ways to assist immune-compromised patients to fight off a variety of pathogens, the authors say.

“We can start to think about how to mimic these chemical processes and deliver them in drug form,” said John D. MacMicking, associate professor of microbial pathogenesis at Yale School of Medicine and senior author the study. (more…)

Computerizing Critical Information: GTRI Supports Health Resources Information Systems in Kenya and Zimbabwe

By Guest PostFebruary 13, 20111 commentHealth, Technologyafrican nations, aids, automate, christopher skeels, computer database, emory university, george bush, gtri, health care, health planning, hiv, human resource information systems, human resource management, judith wold, Kenya, kenya health work force project, khwfp, lillian carter center, malaria, martha rogers, nursing council, robert delano, software, software evaluation protocol, tuberculosis, zimbabwe

Researchers from the Georgia Tech Research Institute (GTRI) are helping to automate human resource information systems for health care professionals in two African nations, Kenya and Zimbabwe.

In collaboration with Emory University’s Lillian Carter Center for International Nursing and the Task Force for Global Health, GTRI is evaluating and advising on computer systems developed to provide information for better human resource management, policy development and health planning. (more…)

Tuberculosis Protects Itself Against Toxic Agents Sent to Destroy It

By Guest PostOctober 12, 2010Health, Sciencebacterium, cleavage function, harsh conditions, immunology, latent tuberculosis, mycobacterium tuberculosis, tapan biswas, tuberculosis, university of michigan

ANN ARBOR, Mich.—Tuberculosis fights off the toxic agents, acidity and oxidants, that our immune system sends to destroy it, which is why the maddeningly drug-resistant bacterium can survive in harsh conditions in our bodies for essentially as long as its human host lives, new research shows. (more…)

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