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U-M Researchers Identify Protein Essential for Cell Division in Blood-forming Stem Cells

By Guest PostDecember 3, 2010Scienceampk, blood-forming stem cells, cell death, cell therapies, cellular metabolism, chromosomes, daisuke nakada, daughter cells, degenerative diseases, energy production, lkb1, normal cell division, protein, protein kinase, sean morrison, stem cell biology, stem cell function, stem cells, thomas saunders, tumor suppressor

ANN ARBOR, Mich.— University of Michigan researchers have discovered that a protein known to regulate cellular metabolism is also necessary for normal cell division in blood-forming stem cells. Loss of the protein results in an abnormal number of chromosomes and a high rate of cell death.

The finding demonstrates that stem cells are metabolically different from other blood-forming cells, which can divide without the protein, Lkb1. This metabolic difference could someday be used to better control the behavior of blood-forming stem cells used in disease treatments, said Sean Morrison, director of the U-M Center for Stem Cell Biology, which is based at the Life Sciences Institute. (more…)

Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass

By Guest PostNovember 13, 20102 commentsScienceaging, bradley olwin, cell transplant, chronic, degenerative muscle diseases, green fluorescent protein, leg muscles, mice, muscle function, muscle stem cells, myofibers, satellite cells, stem cells, transplant, ultraviolet light, university of colorado at boulder

A University of Colorado at Boulder-led study shows that specific types of stem cells transplanted into the leg muscles of mice prevented the loss of muscle function and mass that normally occurs with aging, a finding with potential uses in treating humans with chronic, degenerative muscle diseases.

The experiments showed that when young host mice with limb muscle injuries were injected with muscle stem cells from young donor mice, the cells not only repaired the injury within days, they caused the treated muscle to double in mass and sustain itself through the lifetime of the transplanted mice. “This was a very exciting and unexpected result,” said Professor Bradley Olwin of CU-Boulder’s molecular, cellular and developmental biology department, the study’s corresponding author. (more…)

New Insights into How Stem Cells Determine What Tissue to Become

By Guest PostAugust 1, 20101 commentSciencechristopher chen, immunofluorescence image, jianping fu, matrix, mesenchymal stem cell, microposts, regenerative therapies, silly putty, stem cells

ANN ARBOR, Mich.—Within 24 hours of culturing adult human stem cells on a new type of matrix, University of Michigan researchers were able to make predictions about how the cells would differentiate, or what type of tissue they would become. Their results are published in the Aug. 1 edition of Nature Methods.

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Tag Archives: stem cells

U-M Researchers Identify Protein Essential for Cell Division in Blood-forming Stem Cells

Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass

New Insights into How Stem Cells Determine What Tissue to Become