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Form, Function and Folding: In Collaboration with Berkeley Lab, a Team of Scientists Move Toward Rational Design of Artificial Proteins

By Guest PostAugust 26, 2012Scienceamino acid, barney yoo, berkeley lab, bioinspired nanomaterial, blind structure, function, glenn butterfoss, ilya chorny, jonathan jaworski, ken dill, kent kirshenbaum, modeling, molecular foundry, n alkyl, natural selection, new york university, peptoid molecule, peptoid trimers, prediction, protein, protein sequence, qm, qm calculation, remd, richard bonneau, ronald zuckermann, stony brook university, structure, synthetic cousin, temple university, vincent voelz, xray crystallography

In the world of proteins, form defines function. Based on interactions between their constituent amino acids, proteins form specific conformations, folding and twisting into distinct, chemically directed shapes. The resulting structure dictates the proteins’ actions; thus accurate modeling of structure is vital to understanding functionality.

Peptoids, the synthetic cousins of proteins, follow similar design rules. Less vulnerable to chemical or metabolic breakdown than proteins, peptoids are promising for diagnostics, pharmaceuticals, and as a platform to build bioinspired nanomaterials, as scientists can build and manipulate peptoids with great precision. But to design peptoids for a specific function, scientists need to first untangle the complex relationship between a peptoid’s composition and its function-defining folded structure. (more…)

Diamond in The Rough: Half-Century Puzzle Solved

By Guest PostJuly 25, 2012Sciencecold compressed, conduct, Diamond, electricity, experiment, graphite, hard material, high pressure, industrial application, joseph panzik, m carbon, oakland university, optical technique, puzzle, raman spectroscopy, structure, symmetry, synthesize, university, xray diffraction, yale, yuejian wang

A Yale-led team of mineral physicists has for the first time confirmed through high-pressure experiments the structure of cold-compressed graphite, a form of carbon that is comparable in hardness to its cousin, diamond, but only requires pressure to synthesize. The researchers believe their findings could open the way for a super hard material that can withstand great force and can be used — as diamond-based materials are now — for many electronic and industrial applications. The study appears in Scientific Reports, a Nature journal.

Under normal conditions, pure carbon exhibits vastly different physical properties depending on its structure. For example, graphite is soft, but diamond is one of the hardest materials known. Graphite conducts electricity, but diamond is an insulator. (more…)

Diamonds and Dust for Better Cement

By Guest PostDecember 15, 2011Scienceadvanced light source, als, atomic scale structure, baking limestone, basic materials, beam of x rays, bulk modulus, c s h, calcium carbonate, calcium ions, calcium silicate hydrate, calipso, carbon dioxide, clay, clinker, CO2 emissions, diamonds, diffraction patterns, durability of concrete, human activity, hydrostatic pressure, mineral tobermorite, models, nanoscale, paulo monteiro, performance of cement, portland cement, practical alternatives, pressure, quaint village, scottish isle of mull, silicates, simon clark, southern california, stiffness, structure, surface of earth, university of california at berkeley, versatile concrete, water molecules

Structural studies at Berkeley Lab’s Advanced Light Source could point to reduced carbon emissions and stronger cements

It’s no surprise that humans the world over use more water, by volume, than any other material. But in second place, at over 17 billion tons consumed each year, comes concrete made with Portland cement. Portland cement provides the essential binder for strong, versatile concrete; its basic materials are found in many places around the globe; and, at about $100 a ton, it’s relatively cheap. Making it, however, releases massive amounts of carbon dioxide, accounting for more than five percent of the total CO₂ emissions from human activity.

“Portland cement is the most important building material in the world,” says Paulo Monteiro, a professor of civil and environmental engineering at the University of California at Berkeley, “but if we are going to find ways to use it more efficiently – or just as important, search for practical alternatives – we need a full understanding of its structure on the nanoscale.” To this end Monteiro has teamed with researchers at the U.S. Department of Energy’s Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory. (more…)

Delving Into Manganite Conductivity

By Guest PostFebruary 14, 2011Sciencealexander goncharov, atmospheres, breakthrough, chemical compounds, conductivity, electric charges, jahn teller effect, lamno3, magnetic random access memories, magnetic sensors, magnetoresistance, manganites, maria baldini, metallic state, mysterious ways, non conductive insulating state, spintronic devices, structure, viktor struzhkin

Washington, D.C.— Chemical compounds called manganites have been studied for many years since the discovery of colossal magnetoresistance, a property that promises important applications in the fields of magnetic sensors, magnetic random access memories and spintronic devices. However, understanding—and ultimately controlling—this effect remains a challenge, because much about manganite physics is still not known. A research team lead by Maria Baldini from Stanford University and Carnegie Geophysical Laboratory scientists Viktor Struzhkin and Alexander Goncharov has made an important breakthrough in our understanding of the mysterious ways manganites respond when subjected to intense pressure. (more…)

Tag Archives: structure

Form, Function and Folding: In Collaboration with Berkeley Lab, a Team of Scientists Move Toward Rational Design of Artificial Proteins

Diamond in The Rough: Half-Century Puzzle Solved

Diamonds and Dust for Better Cement

Delving Into Manganite Conductivity