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The Search for the Earliest Signs of Alzheimer’s

By Guest PostMay 30, 2012Health, Sciencealzheimer's disease, alzheimers, azheimers patient, berkeley lab, beta amyloid, beta amyloid plaque, brain checkup, brain function, c 11 pib, city of berkeley, cognitive decline, computed tomography, ct scanner, dan krotz, destructive protein, earliest signs, functional mri scans, hippocampus atrophy, magnetic resonance imaging, mri scans, PET, pet image, positron emission tomography, radiotracer, william jagust

Berkeley Lab scientists help paint a more complicated picture of the devastating disease

For the past five years, volunteers from the City of Berkeley and surrounding areas have come to Lawrence Berkeley National Laboratory to participate in an ongoing study that’s changing what scientists know about Alzheimer’s disease.

The volunteers, most over the age of 70, undergo what can best be described as a brain checkup. They’re asked to solve puzzles and memorize lists of words. Magnetic resonance imaging (MRI) scans image the structure of their brains in exquisite detail. Functional MRI scans allow scientists to watch portions of their brains light up as they form memories. And Positron emission tomography (PET) scans measure any accumulation of beta-amyloid, a destructive protein that’s a hallmark of Alzheimer’s. (more…)

Study Amplifies Understanding of Hearing in Baleen Whales

By Guest PostApril 21, 2012Nature, Science3d visualization, anatomy, auditory system, baleen whale, boston, computerized tomography, csi, ct, darlene ketten, dolphins, evolutionary origin, julie arruda, magnetic resonance imaging, massachusetts, maya yamato, minke whale, mri, scott cramer, sound wave, toothed whale, whoi, zooplankton

For decades, scientists have known that dolphins and other toothed whales have specialized fats associated with their jaws, which efficiently convey sound waves from the ocean to their ears. But until now, the hearing systems of their toothless grazing cousins, baleen whales, remained a mystery.

Unlike toothed whales, baleen whales do not have enlarged canals in their jaws where specialized fats sit. While toothed whales use echolocation to find prey, baleen whales generally graze on zooplankton, and so some scientists have speculated that baleen whales may not need such a sophisticated auditory system. But a new study by scientists at Woods Hole Oceanographic Institution (WHOI), published April 10, 2012, in The Anatomical Record, has shown that some baleen whales also have fats leading to their ears. (more…)

Yale Research Offers New Way To See Inside Solids

By Guest PostMarch 20, 2012Science3d mris, animal bone, array, artifact, assess, biological sample, bone quality, cow bone, gas bearing rock, hydrogen atom, joseph a madri, joshua n vanhouten, karl l insogna, magnetic resonance imaging, material, merideth a frey, michael michaud, mouse liver, mri, oil, phosphorus content, quadratic echo mri, quantum computing, radio wave, sean barrett, solid object, technique, tissue, yale university

Researchers at Yale University have developed a new way of seeing inside solid objects, including animal bones and tissues, potentially opening a vast array of dense materials to a new type of detailed internal inspection.

The technique, a novel kind of magnetic resonance imaging (MRI), creates three-dimensional images of hard and soft solids based on signals emitted by their phosphorus content. (more…)

Researchers Make Living Model of Brain Tumor

By Guest PostFebruary 20, 2012Science3 d characteristics, 3 d model, 3d glioma model, agarose hydrogel mold, anti therapeutic agent, aruna sigdel, blood vessel, brain tumor, brown university, chenjie xu, concept, diameter, diffusion, don ho, endothelial cell, glioma, iron oxide nanoparticles, jeffrey morgan, magnetic resonance imaging, microns, microtissues, nanocarrier, nathan kohler, petri dish, raghu kalluri, rat, rg2 cell gliomas, richard lewis, shouheng sun, tissue culture, tissue model, tumstatin

*Researchers have created a living 3-D model of a brain tumor and its surrounding blood vessels. In experiments, the scientists report that iron-oxide nanoparticles carrying the agent tumstatin were taken by blood vessels, meaning they should block blood vessel growth. The living-tissue model could be used to test the effectiveness of nanoparticles in fighting other diseases. Results appear in Theranostics.*

PROVIDENCE, R.I. [Brown University] — Brown University scientists have created the first three-dimensional living tissue model, complete with surrounding blood vessels, to analyze the effectiveness of therapeutics to combat brain tumors. The 3-D model gives medical researchers more and better information than Petri dish tissue cultures.

The researchers created a glioma, or brain tumor, and the network of blood vessels that surrounds it. In a series of experiments, the team showed that iron-oxide nanoparticles ferrying the chemical tumstatin penetrated the blood vessels that sustain the tumor with oxygen and nutrients. The iron-oxide nanoparticles are important, because they are readily taken up by endothelial cells and can be tracked by magnetic resonance imaging. (more…)

At a Loss for Words

By Guest PostNovember 20, 2011Health, Scienceaphasia, aphasia research project, biological and cognitive processes, brain, brain damage, brain impairs, bullet, celeste barajas, communication impairments, gabrielle giffords, human communication problems, inability to speak or write, language and hearing sciences, language impairment, language recovery, loss of phonology, magnetic resonance imaging, mechanisms of recovery, mri, national institutes of health, network of brain regions, neuroimaging, pelagie beeson, pima county, rehabilitation, scanner, speech, speech language pathology, steven rapcsak, stroke, traumatic brain injury, university of arizona

*Research into aphasia – the inability to speak or write well-formulated sentences and words – is strong at the UA. Researchers have received $2 million toward the study of the condition.*

The National Institutes of Health have awarded the University of Arizona’s Aphasia Research Project in the department of speech, language and hearing sciences a $2 million grant to research communication impairments in adults who have suffered brain injury.

Aphasia – the inability to speak or write well-formulated sentences and words – is a common result of a stroke or a traumatic brain injury such as the one suffered by Rep. Gabrielle Giffords, who was shot in the head earlier this year. The bullet damaged regions of the brain that are critical for language and control of the right side of the body. (more…)

Tag Archives: magnetic resonance imaging

The Search for the Earliest Signs of Alzheimer’s

Study Amplifies Understanding of Hearing in Baleen Whales

Yale Research Offers New Way To See Inside Solids

Researchers Make Living Model of Brain Tumor

At a Loss for Words