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Ovarian Cancer Study Proves Drug Delays Disease Progression

By Guest PostJanuary 3, 2012Healthamerican study, amit oza, avastin, bevacizumab, blood vessels, brain, breast, canada, canadian cancer society, caz zyvatkauskas, colorectal, disease, drug, kidney, lung, oncologist, ovarian cancer, starving the cancer, timothy perren, tumours, university of toronto, women

*U of T, U.K. study focused on Avastin*

Treating ovarian cancer with the drug bevacizumab (“Avastin”) delays the disease and may also improve survival, according to an international clinical trial co-led by Drs. Amit Oza of the University of Toronto and Princess Margaret Hospital (PMH) and Timothy Perren of St James’s Institute of Oncology, Leeds, U.K.

The findings, published on Dec. 28 in the New England Journal of Medicine, report that the drug halted the cancer’s return for two months overall. However, for women with the highest risk disease, the delay was five to six months and in this group, the findings also indicate a strong trend to improved overall survival, which is being analysed until 2013. (more…)

Yale Researchers Find Genetic Link Between Heart Disease and Brain Aneurysms

By Guest PostNovember 25, 2011Health, ScienceAli Ozturk, aneurysms, atherosclerosis, blood vessels, brain, bursting blood vessels, cardiovascular disorders, constriction of blood vessels, DNA, elasticity, endothelin receptor, genes, genetic risk factors, heart disease, hypertension, intracranial aneurysms, Katsuhito Yasuno, Kaya Bilguvar, mehmet bakircioglu, murat gunel, Richard Lifton, Shrikant Mane, variant of gene, vasospasm, vessel spasm, vessel tone

Yale School of Medicine researchers have discovered that a variant of a gene linked to heart disease also increases the risk of deadly aneurysms of blood vessels in the brain. The discovery of this link raises hopes for new treatments for intracranial aneurysms, which affect more than a half million people worldwide annually.

“Existing drugs already target this common pathway and, in the future, could help treat or prevent aneurysms in people who are at risk,” said Murat Gunel, professor of neurosurgery, genetics and neurobiology and senior author of the study, published the week of Nov. 21 in the Proceedings of the National Academy of Sciences. (more…)

‘Back-up system’ Reduces Heart Disease Deaths

By Guest PostOctober 3, 2011Health, Scienceback up system, blood vessels, bypass vessels, christian seiler, clotted coronary artery, coronary artery disease, coronary collaterals, counterpulsation, g csf, growth factor, heart disease, heart main arteries, pascal meier, patients with a heart attack, role of natural bypass vessels, university of bern, yale university

Small bypass vessels which act as a ‘back-up system’ for the heart’s main arteries play a significant role in reducing the mortality of patients with coronary artery disease, according to new research. (more…)

Sea Squirt Cells Shed Light on Cancer Development

By Guest PostJuly 28, 2011Scienceblood vessels, bradley davidson, cancer cells, cancer therapy, cancerous mutations, cell types, ciona embryo, control mechanisms, elimination processes, embryos, epithelial barriers, growth factors, heart cells, heart progenitor cell, invadopodia, laser microscope, model organism, natural barriers, periods of time, sea squirt, sea squirt ciona intestinalis, tissues, tumors, university of arizona, vertebrates

*Specialized structures used by cancer cells to invade tissues could also help them escape protection mechanisms aimed at eliminating them, a UA-led research team has discovered.*

Delicate, threadlike protrusions used by cancer cells when they invade other tissues in the body could also help them escape control mechanisms supposed to eliminate them, a research group led by led by Bradley Davidson in the University of Arizona’s department of molecular and cellular biology reports in Nature Cell Biology.

Studying embryos of the sea squirt Ciona intestinalis, the researchers discovered that even non-invasive cells make the delicate, highly transient structures known as invadopodia. The group found that future heart cells in the Ciona embryo use invadopodia to pick up chemical signals from their surroundings. These so-called growth factors provide the cells with clues as to where they are in the developing embryo and what type of cell they are supposed to turn into. (more…)

Tag Archives: blood vessels

Ovarian Cancer Study Proves Drug Delays Disease Progression

Yale Researchers Find Genetic Link Between Heart Disease and Brain Aneurysms

‘Back-up system’ Reduces Heart Disease Deaths

Sea Squirt Cells Shed Light on Cancer Development