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UCLA study sheds light on how advanced melanoma resists treatment

Findings are a promising step toward developing improved treatments for the disease

UCLA researchers have identified mechanisms that determine how advanced melanoma can become resistant to immune checkpoint inhibitors, a discovery that could lead to the development of new and improved treatments for the deadliest type of skin cancer. (more…)

Cancer Genes Differ in Different Parts of a Tumour

By Guest PostMarch 17, 2012Health, Sciencebiomarkers, biopsies, biopsy, cancer cell, cancer treatment, charles swanton, gene faults, genetic fault, genetic landscape, genetic variation, genome, genome sequencing technology, james larkin, kidney cancer, kidney tumours, lesley walker, molecular change, mutation, primary tumour, subtype, theory, tree of life, tumour, ubiquitous mutations

Taking a sample from just one part of a tumour may not give a full picture of its‘genetic landscape’, according to a study published in the New England Journal of Medicine.

The findings could help explain why attempts at using single biopsies to identify biomarkers to which personalised cancer treatments can be targeted have not been more successful. (more…)

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UCLA study sheds light on how advanced melanoma resists treatment

Cancer Genes Differ in Different Parts of a Tumour