COLUMBUS, Ohio – A team of researchers is beginning to see exactly what the response to threats looks like in the brain at the cellular and molecular levels. (more…)
Yale University researchers have identified four unique host defense proteins among thousands that seem to play a crucial role in mobilizing the immune system’s response to bacterial infections, they report in the May 6 issue of the journal Science.
The findings suggest it may be possible to find new ways to assist immune-compromised patients to fight off a variety of pathogens, the authors say.
“We can start to think about how to mimic these chemical processes and deliver them in drug form,” said John D. MacMicking, associate professor of microbial pathogenesis at Yale School of Medicine and senior author the study. (more…)
GAINESVILLE, Fla. — When a movie character says, “It’s too quiet,” that’s usually a sign something bad may happen.
Now, University of Florida researchers have discovered that when variations of a certain protein in our cells are too quiet, it may add to the risk that someone will develop lung cancer. When scientists restored the protein to its normal, active self, its cancer-inhibiting properties reappeared. (more…)
Thanks in part to studies that follow subjects for a long time, psychologists are learning more about differences between people. In a new article published in Current Directions in Psychological Science, a journal of the Association for Psychological Science, the author describes how psychologists can use their data to learn about the different ways that people’s minds work.
Most psychology research is done by asking a big group of people the same questions at the same time. “So we might get a bunch of Psych 101 undergrads, administer a survey, ask about how much they use alcohol and what their mood is, and just look and see, is there a relationship between those two variables,” says Daniel J. Bauer of the University of North Carolina at Chapel Hill, the author of the article. (more…)
The size and shape of the human cerebral cortex, an evolutionary marvel responsible for everything from Shakespeare’s poetry to the atomic bomb, are largely influenced by mutations in a single gene, according to a team of researchers led by the Yale School of Medicine and three other universities. (more…)
For over 25 years, Dr. John M. Leventhal has been fighting a battle to protect the lives of hundreds of children who come through one of the child abuse programs at Yale.
He has won many struggles along the way, but to win the war, he says, the program needs to be armed with more state and federal support, as well as support from individuals and foundations.
“Finding ways to protect children who can’t defend themselves is part of what wakes me up in the morning and motivates me to continue this tough, but important work,” says Leventhal, professor of pediatrics at Yale School of Medicine and director of the Child Abuse Programs at Yale-New Haven Children’s Hospital. (more…)
ANN ARBOR, Mich.— For the first time, scientists have made star-shaped, biodegradable polymers that can self-assemble into hollow, nanofiber spheres, and when the spheres are injected with cells into wounds, these spheres biodegrade, but the cells live on to form new tissue. (more…)
It is well known that the human body has a highly developed immune system to detect and destroy invading pathogens and tumor cells. Now, researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have shown that the body has a second line of defense against cancer – healthy cells. A new study shows that normal mammary epithelial cells, as they are developing, secrete interleukin 25, a protein known for its role in the immune system’s response to inflammation, for the express purpose of killing nearby breast cancer cells.
“We found that normal breast cells provide an innate defense mechanism against cancer by producing interleukin 25 (IL25) to actively and specifically kill breast cancer cells,” says breast cancer authority Mina Bissell, of Berkeley Lab’s Life Sciences Division, who led this research. “This suggests that IL25 receptor signaling may provide a new therapeutic target for the treatment of breast cancer.” (more…)
