Tag Archives: neurological diseases

Tau-tally Microtubular!

By Science, , , , , , ,

Structural model of physiological tau-microtubule interactions sheds light on neurological diseases that correlate with their disruption

Researchers at Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California, Berkeley have combined cutting-edge cryo-­electron microscopy (cryo-EM) with computational molecular modeling to produce a near-atomic-resolution model of the interaction between microtubules – crucial components of eukaryotic cell ultrastructure – and microtubule-associated proteins called tau. (more…)

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The terrifying rise of the Gothic

By Culture, , , , , , , , , , , , , , ,

To mark the 250th anniversary of the earliest Gothic novel, first published on Christmas Eve 1764 as a seasonal ghost story, a new edition of The Castle of Otranto introduced by a University of Exeter academic is now available.

Author Horace Walpole described his literary work as a “Gothic story”, yet for him the Gothic meant very different things from what it might do today. While the Gothic was associated with the supernatural, it was predominantly a theory of English progress rooted in Anglo Saxon and medieval history. (more…)

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Huntington’s Disease

By Health, , , , ,

UD researchers develop novel technique for early detection of misfolded protein

University of Delaware assistant professor David W. Colby is co-author of a paper in the March 23 issue of the Journal of Biological Chemistry that suggests protein misfolding may occur early in the pathogenesis, or development, of Huntington’s disease. (more…)

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