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The Rise of Zika—Another Mosquito Virus in the Americas

Zika, the latest mosquito-borne virus to emerge in the Americas, is rapidly becoming a public health crisis. In Brazil, it is suspected in a sharp increase in microcephaly (a birth defect that results in newborns with smaller than normal head size), leading to anxiety amongst expecting mothers and a travel advisory from the Centers for Disease Control and Prevention. Traditionally, the virus has been fairly benign, causing a rash and a fever that is usually non-life threatening. Professor Albert Ko, chair of the Department of Epidemiology of Microbial Diseases at the Yale School of Public Health, has been working with colleagues in Brazil for months to understand if the virus has changed and what is causing the birth defects in newborns. (more…)

Mystery of the mutant polyomavirus

By Guest PostJuly 7, 2013Health, Scienceaaron derdowski, astrocytes, bethany ohara, brain glial cells, brown university, carbohydrate, crystal structure, DNA, gretchen gee, infectious, jc polyomavirus, lstc, luisa ströh, melissa maginnis, mutant form, mutant polyomavirus, myelin, mystery, non infection, oligodendrocytes, pathogen, pml, progressive multifocal leukoencephalopathy, thilo stehle, university of tübingen, ursula neu, vanderbilt university, virus, walter atwood, wild type, xray crystallography

A new study shows that common mutant forms of the deadly JC polyomavirus are not responsible for the pathogen’s main attack, which causes a brain-damaging disease in immunocompromised patients called progressive multifocal leukoencephalopathy. But that finding raises the ominous question of what the mutants might be up to instead.

PROVIDENCE, R.I. [Brown University] — The JC polyomavirus is clearly opportunistic. It infects half the population but lethally destroys brain tissue only in immunocompromised patients — and it may be outright sneaky, too. Even as a new research paper allays fears that common mutant forms of the virus are the ones directly responsible for the disease’s main attack, that same finding raises new questions about what the mutants are doing instead. (more…)

Tag Archives: infectious

The Rise of Zika—Another Mosquito Virus in the Americas

Mystery of the mutant polyomavirus