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Protein ‘Jailbreak’ Helps Cancer Cells Live

By Guest PostMarch 28, 2012Scienceacetylation, breast cancer, brown university, cancer cell, cbp, cell, crm1, hasbro childrens hospital, hdac6, jailbreak, matthew riolo, michael holloway, nucleus, proteins survivin, rachel altura, survivin, yan cheng, zachary cooper

Researchers at Brown University and Hasbro Children’s Hospital have traced the molecular interactions that allow the protein survivin to escape the nucleus of a breast cancer cell and prolong the cell’s life. The study may help in the development of better therapies and prognostics.

PROVIDENCE, R.I. [Brown University] — If the fight against breast cancer were a criminal investigation, then the proteins survivin, HDAC6, CBP, and CRM1 would be among the shadier figures. In that vein, a study to be published in the March 30 Journal of Biological Chemistry is the police report that reveals a key moment for keeping cancer cells alive: survivin’s jailbreak from the nucleus, aided and abetted by the other proteins. The research highlights that a protein’s location in a cell affects its impact on disease, and offers clear new leads for the investigation. (more…)

Cancer Genes Differ in Different Parts of a Tumour

By Guest PostMarch 17, 2012Health, Sciencebiomarkers, biopsies, biopsy, cancer cell, cancer treatment, charles swanton, gene faults, genetic fault, genetic landscape, genetic variation, genome, genome sequencing technology, james larkin, kidney cancer, kidney tumours, lesley walker, molecular change, mutation, primary tumour, subtype, theory, tree of life, tumour, ubiquitous mutations

Taking a sample from just one part of a tumour may not give a full picture of its‘genetic landscape’, according to a study published in the New England Journal of Medicine.

The findings could help explain why attempts at using single biopsies to identify biomarkers to which personalised cancer treatments can be targeted have not been more successful. (more…)

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

Tag Archives: cancer cell

Protein ‘Jailbreak’ Helps Cancer Cells Live

Cancer Genes Differ in Different Parts of a Tumour

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells