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Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

By Guest PostJanuary 27, 2013Sciencealuminum substrate, anatoli melechko, balloon, bed of nails, brain, bryan anderson, carbon nanofibers, drug delivery systems, elastic membrane, elastic silicone membrane, embedding carbon nanofibers, joseph tracy, justin railsback, liquid silicone polymer, mehmet sarac, nanofibers, nanoscale, needle like, north Carolina, ryan pearce, state university, technique, timothy mcknight

Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible “bed of nails” on the nanoscale that opens the door to development of new drug-delivery systems.

The research community is interested in finding new ways to deliver precise doses of drugs to specific targets, such as regions of the brain. One idea is to create balloons embedded with nanoscale spikes that are coated with the relevant drug. Theoretically, the deflated balloon could be inserted into the target area and then inflated, allowing the spikes on the balloon’s surface to pierce the surrounding cell walls and deliver the drug. The balloon could then be deflated and withdrawn. (more…)

‘Bed-of-Nails’ Breast Implant Deters Cancer Cells

Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.

PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)

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Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

‘Bed-of-Nails’ Breast Implant Deters Cancer Cells