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New Information on the Waste-Disposal Units of Living Cells

By Guest PostJanuary 15, 2012Sciencecellular process, cellular proteins, living cells, proteasome process, subnanometer scale, waste disposal

Berkeley Researchers Provide Detailed Look at Proteasome’s Regulatory Particle

Important new information on one of the most critical protein machines in living cells has been reported by a team of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. The researchers have provided the most detailed look ever at the “regulatory particle” used by the protein machines known as proteasomes to identify and degrade proteins that have been marked for destruction. The activities controlled by this regulatory particle are critical to the quality control of cellular proteins, as well as a broad range of vital biochemical processes, including transcription, DNA repair and the immune defense system. (more…)

Sewing the Inner, Creative Mind

By Guest PostJanuary 14, 2012Culture, Environmentcreative mind, perfectionist, reformed perfectionist, sewing machine, solar power

UA alumnus Paul Nosa travels with his solar powered sewing machine, stitching patches of the thoughts people choose to share with him

Paul Nosa is a perfectionist – well, a reformed perfectionist. (more…)

Research Focuses on Youth, Chronic Illness and Employment

By Guest PostJanuary 14, 2012Economy, Healthchronic illness, employment, good health, juvenile arthritis, spinal disorders, young adults

PhD candidate explores their interconnection

Like any 28 year old, Arif Jetha, a fourth-year PhD candidate at the University of Toronto’s Dalla Lana School of Public Health, is worrying about his future. Once he completes his PhD, should he remain at home with his parents and pursue post-doctoral work or move on to full-time employment and begin establishing his career? (more…)

Timely Ends: Telomere Length in Early Life Predicts Lifespan

By Guest PostJanuary 14, 2012Scienceblood cells, britt heidinger, cells, chromosomes, conditions, DNA, dna protection, environmental factors, exeter, function, genetic code, jon blount, lifespan, malfunction, plastic caps, predictor of longevity, telomere cap, telomere lengths, telomeres, universities of glasgow, zebra finches

New research by a team from the Universities of Glasgow and Exeter shows that a good indicator of how long individuals will live can be obtained from early in life using the length of specialised pieces of DNA called telomeres.

Telomeres occur at the ends of the chromosomes, which contain our genetic code.

They function a bit like the plastic caps at the end of shoelaces by marking the chromosome ends and protecting them from various process that gradually cause the ends to be worn away. This method of DNA protection is the same for most animals and plants, including humans, and the eventual loss of the telomere cap is known to cause cells to malfunction. This study is the first in which telomere length has been measured repeatedly from early in life of an individual and then for the rest of their natural lives. The results show that telomere length in early life is strongly predictive of lifespan. (more…)

English Literature Influenced Prize-Winning Paleontologist

By Guest PostJanuary 14, 2012Science21st century, age of reptiles, ancient plant structure, carbon cycle, carboniferous period, cocktail party, dinosaurs, earth, ecology, evolution, excalibur movie, fieldwork, fossil record, giant fungus, harvard university, history of life, ice age, jung eun lee, kevin boyce, knowledge, la brea tar pits, lloyd degrane, los angeles, macroevolution, mammal fossils, michael foote, million years ago, mural, pair of calipers, paleontology, plant fossils, prehistoric life, scanning electron microscope, school, soil moisture, terrestrial ecosystems, vascular plants

For a short time in grade school, Kevin Boyce lived within two blocks of the La Brea tar pits in Los Angeles, a place where ice age mammal fossils had been discovered. Above his bed hung a poster of the Yale Peabody Museum’s famous Age of Reptiles mural. But it wasn’t a boyhood fascination with prehistoric life that influenced his interest in paleontology, but rather the medieval literary world of Chaucer that Boyce discovered in college.

“I didn’t think twice about fossils between the ages of 7 and 20,” said Boyce, associate professor in geophysical sciences. Even during his undergraduate studies in literature and biology at the California Institute of Technology in the early 1990s, the deep history of life on Earth was far from his mind. (more…)

Clearing a Potential Road Block to Bisabolane

By Guest PostJanuary 14, 2012Scienceabies grandis, abies grandis α bisabolene synthase, advanced biofuels, agbis, andy degiovanni, berkeley lab, biofuel, biosynthetic alternative, bisabolane, ca, chemical compounds, cofactors, d2 diesel fuel, emeryville, enzyme, evolutionary heritage, flavorings, fragrances, grand fir, green energy, inhibitors, jay keasling, jose pereira, masood hadi, microbes, microbial based production, pamela peralta yahya, paul adams, precursor, protein, protein crystal structure, renewable alternative, resolution, ryan mcandrew, synthases in plants, terpene class, terpenoid synthases, three dimensional crystal structure, trucking industry, united states, x ray crystallography

*Joint BioEnergy Institute Researchers Identify Key Enzyme Structure*

The recent discovery that bisabolane, a member of the terpene class of chemical compounds used in fragrances and flavorings, holds high promise as a biosynthetic alternative to D2 diesel fuel has generated keen interest in the green energy community and the trucking industry. Now a second team of researchers with the U.S Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) has determined the three-dimensional crystal structure of a protein that is key to boosting the microbial-based production of bisabolane as an advanced biofuel.

The JBEI research team, led by bioengineers Paul Adams and Jay Keasling, solved the protein crystal structure of an enzyme in the Grand fir (Abies grandis) that synthesizes bisabolene, the immediate terpene precursor to bisabolane. The performance of this enzyme – the Abies grandis α-bisabolene synthase (AgBIS) – when engineered into microbes, has resulted in a bottleneck that hampers the conversion by the microbes of simple sugars into bisabolene. (more…)

At 10-Year Milestone, Microsoft’s Trustworthy Computing Initiative More Important than Ever

By Guest PostJanuary 13, 2012Technologymicrosoft products, microsoft software, trustworthy computing, windows error reporting

Industry collaboration critical to helping businesses, governments and citizens realize safer computing experiences.

REDMOND, Wash. – Ten years ago this week, during a time when security problems were threatening trust in software products, Bill Gates sent an email to all Microsoft full-time employees announcing the creation of the Trustworthy Computing (TwC) initiative. A pivotal moment in the company’s history, Gates defined the key aspects of Trustworthy Computing, stating the company must make this initiative the highest priority. (more…)

Gut Microbe Networks Differ From Norm in Obese People, Systems Biology Approach Reveals

By Guest PostJanuary 13, 2012Healthbowel disease, gut microbiome, metabolic potential, obese microbiomes, obese people, supra organism

For the first time, researchers have analyzed the multitude of microorganisms residing in the human gut as a complex, integrated biological system, rather than a set of separate species. Their approach has revealed patterns that correspond with excess body weight. (more…)

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