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Yale’s New Microscope Brings Atoms’ Identities into Focus

Yale’s acquisition of a powerful new transmission electron microscope (TEM) is expected to transform researchers’ ability to examine and manipulate atom-scale materials and devices on campus.

The approximately $2 million, state-of-the-art microscope offers atomic resolution for both physical structure and chemical composition, as well as significantly faster processing times than other devices on campus. It is the first unit of this specific TEM model acquired for university laboratory use. (more…)

NASA’s Kepler Mission Finds Three Smallest Exoplanets

PASADENA, Calif. – Astronomers using data from NASA’s Kepler mission have discovered the three smallest planets yet detected orbiting a star beyond our sun. The planets orbit a single star, called KOI-961, and are 0.78, 0.73 and 0.57 times the radius of Earth. The smallest is about the size of Mars.

All three planets are thought to be rocky like Earth but orbit close to their star, making them too hot to be in the habitable zone, which is the region where liquid water could exist. Of the more than 700 planets confirmed to orbit other stars, called exoplanets, only a handful are known to be rocky. (more…)

New Information on the Waste-Disposal Units of Living Cells

Berkeley Researchers Provide Detailed Look at Proteasome’s Regulatory Particle

Important new information on one of the most critical protein machines in living cells has been reported by a team of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. The researchers have provided the most detailed look ever at the “regulatory particle” used by the protein machines known as proteasomes to identify and degrade proteins that have been marked for destruction. The activities controlled by this regulatory particle are critical to the quality control of cellular proteins, as well as a broad range of vital biochemical processes, including transcription, DNA repair and the immune defense system. (more…)

Sewing the Inner, Creative Mind

UA alumnus Paul Nosa travels with his solar powered sewing machine, stitching patches of the thoughts people choose to share with him

Paul Nosa is a perfectionist – well, a reformed perfectionist. (more…)

Research Focuses on Youth, Chronic Illness and Employment

PhD candidate explores their interconnection

Like any 28 year old, Arif Jetha, a fourth-year PhD candidate at the University of Toronto’s Dalla Lana School of Public Health, is worrying about his future. Once he completes his PhD, should he remain at home with his parents and pursue post-doctoral work or move on to full-time employment and begin establishing his career? (more…)

Timely Ends: Telomere Length in Early Life Predicts Lifespan

New research by a team from the Universities of Glasgow and Exeter shows that a good indicator of how long individuals will live can be obtained from early in life using the length of specialised pieces of DNA called telomeres.

Telomeres occur at the ends of the chromosomes, which contain our genetic code.

They function a bit like the plastic caps at the end of shoelaces by marking the chromosome ends and protecting them from various process that gradually cause the ends to be worn away. This method of DNA protection is the same for most animals and plants, including humans, and the eventual loss of the telomere cap is known to cause cells to malfunction. This study is the first in which telomere length has been measured repeatedly from early in life of an individual and then for the rest of their natural lives. The results show that telomere length in early life is strongly predictive of lifespan. (more…)

English Literature Influenced Prize-Winning Paleontologist

For a short time in grade school, Kevin Boyce lived within two blocks of the La Brea tar pits in Los Angeles, a place where ice age mammal fossils had been discovered. Above his bed hung a poster of the Yale Peabody Museum’s famous Age of Reptiles mural. But it wasn’t a boyhood fascination with prehistoric life that influenced his interest in paleontology, but rather the medieval literary world of Chaucer that Boyce discovered in college.

“I didn’t think twice about fossils between the ages of 7 and 20,” said Boyce, associate professor in geophysical sciences. Even during his undergraduate studies in literature and biology at the California Institute of Technology in the early 1990s, the deep history of life on Earth was far from his mind. (more…)

Clearing a Potential Road Block to Bisabolane

*Joint BioEnergy Institute Researchers Identify Key Enzyme Structure*

The recent discovery that bisabolane, a member of the terpene class of chemical compounds used in fragrances and flavorings, holds high promise as a biosynthetic alternative to D2 diesel fuel has generated keen interest in the green energy community and the trucking industry. Now a second team of researchers with the U.S Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) has determined the three-dimensional crystal structure of a protein that is key to boosting the microbial-based production of bisabolane as an advanced biofuel.

The JBEI research team, led by bioengineers Paul Adams and Jay Keasling, solved the protein crystal structure of an enzyme in the Grand fir (Abies grandis) that synthesizes bisabolene, the immediate terpene precursor to bisabolane. The performance of this enzyme – the Abies grandis α-bisabolene synthase (AgBIS) – when engineered into microbes, has resulted in a bottleneck that hampers the conversion by the microbes of simple sugars into bisabolene. (more…)