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MU Scientists Build Harness for Powerful Radiation Cancer Therapy

By Guest PostFebruary 11, 2013Healthactinium, alpha emitter, alpha particles, beta particles, bone cancer, cancer cells, cancer patients, cancer site, cannon balls, david robertson, gold nanoparticle, gold plated nanoparticle, groundbreaking work, healthy organs, human clinical trials, knoxville, low energy, mark mclaughlin, national laboratory, oak ridge, radiation cancer therapy, radioactive particles, radiopharmaceuticals, radium 223 chloride, tissues, treatments for cancer, tumors for treatment, university of missouri, university of tennessee

Scientists at MU, Oak Ridge National Laboratory and the University of Tennessee at Knoxville created a gold nanoparticle that can transport powerful radioactive particles directly to tumors for treatment.

We’ve all heard that “it’s not wise to use a cannon to kill a mosquito.” But what if you could focus the cannon’s power to concentrate power into a tiny space? In a new study, University of Missouri researchers have demonstrated the ability to harness powerful radioactive particles and direct them toward small cancer tumors while doing negligible damage to healthy organs and tissues. The study is being published this week in PLOS ONE, an international, peer-reviewed and open-access publication. (more…)

Researchers Suggest A Proximate Cause of Cancer

By Guest PostJanuary 26, 2012Health, Science3d cancer model, biochemical carcinogenic factors, biochemical factors, boston university, cancer cells, cancer progression, cancerous behavior, carcinogenic factors, cell, computational model, Environment, genetic, healthy tissue, life cycle, malignant tumor, mechanical factors, mechanical property, muhammad zaman, multiplication rate, parag katira, physical stress, prevent cancer, probability of death, radiation, roger t bonnecaze, softening of cells, stiffer cells, synthetic chemicals, types of cancers, understanding of cancer, university of texas at austin

AUSTIN, TX — Researchers from The University of Texas at Austin’s Department of Chemical Engineering are the first to show that mechanical property changes in cells may be responsible for cancer progression — a discovery that could pave the way for new approaches to predict, treat and prevent cancer.

Postdoctoral student Parag Katira and his adviser, Roger T. Bonnecaze, department chair in the Cockrell School of Engineering and T. Brockett Hudson Professor, worked with Muhammad Zaman of Boston University to devise a 3-D cancer model that shows the softening of cells and changes in cell binding cause cancerous behavior in cells. These mechanical property changes cause cells to divide uncontrollably — making them less likely to die and resulting in malignant tumor growth. The findings present a unique physics-based perspective on understanding cancer progression and were published recently in the American Physical Society’s journal Physical Review Letters. (more…)

Sea Squirt Cells Shed Light on Cancer Development

By Guest PostJuly 28, 2011Scienceblood vessels, bradley davidson, cancer cells, cancer therapy, cancerous mutations, cell types, ciona embryo, control mechanisms, elimination processes, embryos, epithelial barriers, growth factors, heart cells, heart progenitor cell, invadopodia, laser microscope, model organism, natural barriers, periods of time, sea squirt, sea squirt ciona intestinalis, tissues, tumors, university of arizona, vertebrates

*Specialized structures used by cancer cells to invade tissues could also help them escape protection mechanisms aimed at eliminating them, a UA-led research team has discovered.*

Delicate, threadlike protrusions used by cancer cells when they invade other tissues in the body could also help them escape control mechanisms supposed to eliminate them, a research group led by led by Bradley Davidson in the University of Arizona’s department of molecular and cellular biology reports in Nature Cell Biology.

Studying embryos of the sea squirt Ciona intestinalis, the researchers discovered that even non-invasive cells make the delicate, highly transient structures known as invadopodia. The group found that future heart cells in the Ciona embryo use invadopodia to pick up chemical signals from their surroundings. These so-called growth factors provide the cells with clues as to where they are in the developing embryo and what type of cell they are supposed to turn into. (more…)

Go Figure: Math Model May Help Researchers with Stem Cell, Cancer Therapies

By Guest PostJanuary 24, 2011Science21st century, algorithm, alzheimer, brain tumors, brent reynolds, cancer cells, cancer stem cells, diseases, geoffrey ericksson, harley kornblum, joel e cohen, loic p deleyrolle, math, mathematical steps, microscopes, new microscope, parkinson, progressive diseases, protein assays, queensland brain institute, stem cells, therapeutics

GAINESVILLE, Fla. — The difficult task of sorting and counting prized stem cells and their cancer-causing cousins has long frustrated scientists looking for new ways to help people who have progressive diseases.

But in a development likely to delight math teachers, University of Florida researchers have devised a series of mathematical steps that accomplishes what the most powerful microscopes, high-throughput screening systems and protein assays have failed to do — assess how rapidly stem cells and their malignant, stemlike alter egos increase their numbers. (more…)

Scientists Now Know Why Some Cancers Become Malignant and Others Don’t

By Guest PostJanuary 7, 2011Health, Sciencecanadian cancer society, cancer cells, dr. gerardo ferbeyre, molecule, pml

Cancer cells reproduce by dividing in two, but a molecule known as PML limits how many times this can happen, according to researchers lead by Dr. Gerardo Ferbeyre of the University of Montreal’s Department of Biochemistry. The team proved that malignant cancers have problems with this molecule, meaning that in its absence they can continue to grow and eventually spread to other organs. Importantly, the presence of PML molecules can easily be detected, and could serve to diagnose whether a tumor is malignant or not. (more…)

MU Scientists Find Cinnamon Can Replace Harmful Chemicals Used to Create Nanoparticles

By Guest PostNovember 29, 2010Sciencecancer cells, cinnamon, electronics, fight cancer, gold nanoparticles, green process, kattesh katti, kitchen spice, nanoparticles, non-toxic, norman borlaug, toxic chemicals

*MU scientists make strides in green nanotechnology*

COLUMBIA, Mo. – Gold nanoparticles, tiny pieces of gold so small that they can’t be seen by the naked eye, are used in electronics, healthcare products and as pharmaceuticals to fight cancer. Despite their positive uses, the process to make the nanoparticles requires dangerous and extremely toxic chemicals. While the nanotechnology industry is expected to produce large quantities of nanoparticles in the near future, researchers have been worried about the environmental impact of the global nanotechnological revolution. (more…)

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