Technology

Scientists Dramatically Reduce Plaque-Forming Substances in Mice with Alzheimer’s Disease

COLUMBUS, Ohio – Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer’s disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer’s disease.

That is the most dramatic reduction in this compound reported to date in published research.

The compounds are amyloid beta, or A-beta peptides; peptides are proteins, but are shorter in length. When A-beta peptides accumulate in excessive amounts in the brain, they can form plaques, which are a hallmark of Alzheimer’s disease. (more…)

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Rust Never Sleeps

Berkeley Lab-led Observations of Electron Hopping in Iron Oxide Hold Consequences for Environment and Energy

Rust – iron oxide – is a poor conductor of electricity, which is why an electronic device with a rusted battery usually won’t work. Despite this poor conductivity, an electron transferred to a particle of rust will use thermal energy to continually move or “hop” from one atom of iron to the next. Electron mobility in iron oxide can hold huge significance for a broad range of environment- and energy-related reactions, including reactions pertaining to uranium in groundwater and reactions pertaining to low-cost solar energy devices. (more…)

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Precautions for Tick-Borne Disease Extend “Beyond Lyme”

Save the tick that bites you: it may not be the one you think

This year’s mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast.

While Lyme disease is the most common tick-borne disease in the Northeast and Upper Midwest, new research results emphasize that it is not the greatest cause for concern in most Southeastern states.

The findings are published today in a paper in the journal Zoonoses and Public Health. (more…)

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Blanket Bogs Need Protection from Climate Change

Blanket bogs, which provide vital habitats for a unique range of plants, birds, small mammals, reptiles and amphibians, are at risk of declining as a result of climate change.

Research by the Universities of Exeter and Bristol in the UK and Macquarie University in Australia, published in the journal Nature Climate Change, shows for the first time how rising temperatures will threaten these sensitive ecosystems.

The study highlights the urgency of developing a plan to protect these important habitats.

Found in wet, coastal areas of high latitude regions, blanket bogs cover around 700,000 hectares of land in the UK, much of it designated as a Site of Special Scientific Interest (SSSI). Blanket bogs are found in the north and west of the UK, extending from Devon in the south to Shetland in the north, and it has been estimated that 10 to15 per cent of the world’s blanket bog occurs in Britain. As well as being crucial in supporting wildlife, blanket bogs also capture and store large amounts of carbon, helping to mitigate against climate change, and reduce the risk of flooding, by slowing down water flow. With some blanket peat being over 9,000 years old, they also hold historically-significant archaeological material. (more…)

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The Best Strategy to Defeat HIV in South Africa

UCLA study challenges World Health Organization’s approach

The World Health Organization is about to roll out a new strategy for AIDS prevention in South Africa, a country where more than 5 million people are infected with HIV. Based on a mathematical model, the WHO predicts this strategy will completely eliminate HIV in South Africa within a decade. (more…)

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Dinosaur Die Out Might Have Been Second of Two Closely Timed Extinctions

The most-studied mass extinction in Earth history happened 65 million years ago and is widely thought to have wiped out the dinosaurs. New University of Washington research indicates that a separate extinction came shortly before that, triggered by volcanic eruptions that warmed the planet and killed life on the ocean floor.

The well-known second event is believed to have been triggered by an asteroid at least 6 miles in diameter slamming into Mexico’s Yucatán Peninsula. But new evidence shows that by the time of the asteroid impact, life on the seafloor – mostly species of clams and snails – was already perishing because of the effects of huge volcanic eruptions on the Deccan Plateau in what is now India. (more…)

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Forcing the Molecular Bond Issue

New and Improved Model of Molecular Bonding from Researchers at Berkeley Lab’s Molecular Foundry

Material properties and interactions are largely determined by the binding and unbinding of their constituent molecules, but the standard model used to interpret data on the formation and rupturing of molecular bonds suffers from inconsistencies. A collaboration of researchers led by a scientist at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a first-of-its-kind model for providing a comprehensive description of the way in which molecular bonds form and rupture. This model enables researchers to predict the “binding free energy” of a given molecular system, which is key to predicting how that molecule will interact with other molecules.

“Molecular binding and unbinding events are much simpler than we have been led to believe from the standard model over the past decade,” says Jim DeYoreo, a scientist with the Molecular Foundry, a DOE nanoscience center at Berkeley Lab who was one of the leaders of this research. “With our new model, we now have a clear means for measuring one of the most important parameters governing how materials and molecules bind together.” (more…)

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