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How a Concussion Can Lead to Depression Years Later

After brain injury, cells on ‘high alert’ prolong immune response, affecting behavior

COLUMBUS, Ohio – A head injury can lead immune-system brain cells to go on “high alert” and overreact to later immune challenges by becoming excessively inflammatory – a condition linked with depressive complications, a new animal study suggests.

The findings could help explain some of the midlife mental-health issues suffered by individuals who experience multiple concussions as young adults, researchers say. And these depressive symptoms are likely inflammation-related, which means they may not respond to common antidepressants. (more…)

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