Tag Archives: chromosome

Low Quality Genes May Cause Mutational Meltdown

Deficiencies compound over time, researchers say

Evolutionary biologists at the University of Toronto have found that individuals with low-quality genes may produce offspring with even more inferior chromosomes, possibly leading to the extinction of certain species over generations.

Their study, published in Proceedings of the National Academy of Sciences, predicts that organisms with such genetic deficiencies could experience an increased number of mutations in their DNA, relative to individuals with high-quality genes. The research was done on fruit flies whose simple system replicates aspects of biology in more complex systems, so the findings could have implications for humans. (more…)

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New Molecule Has Potential to Help Treat Genetic Diseases and HIV

AUSTIN, Texas — Chemists at The University of Texas at Austin have created a molecule that’s so good at tangling itself inside the double helix of a DNA sequence that it can stay there for up to 16 days before the DNA liberates itself, much longer than any other molecule reported.

It’s an important step along the path to someday creating drugs that can go after rogue DNA directly. Such drugs would be revolutionary in the treatment of genetic diseases, cancer or retroviruses such as HIV, which incorporate viral DNA directly into the body’s DNA. (more…)

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Frogs Use Calls to Find Mates with Matching Chromosomes, University of Missouri Researchers Find

*Tree frogs that look similar hear chromosome difference in calls; offers new insight to frog evolution*

Columbia, MO – When it comes to love songs, female tree frogs are pretty picky. According to a new study from the University of Missouri, certain female tree frogs may be remarkably attuned to the songs of mates who share the same number of chromosomes as they do. The discovery offers insight into how new frog species may have evolved.

Carl Gerhardt, Curators Professor of Biological Sciences in the MU College of Arts and Science and doctoral student Mitch Tucker studied two closely related species of grey tree frogs that live in Missouri, the eastern grey tree frog (Hyla versicolor) and the Cope’s grey tree frog (H. chrysoscelis). (more…)

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Ancient Humans Were Mixing it Up

*Anatomically modern humans interbred with more archaic hominin forms even before they migrated out of Africa, a UA-led team of researchers has found.*

It is now widely accepted that anatomically modern humans of the species Homo sapiens originated in Africa and eventually spread throughout the world. Ancient DNA recovered from fossil Neanderthal bones suggests they interbred with more archaic hominin forms once they had left their evolutionary cradle for the cooler climates of Eurasia, but whether they exchanged genetic material with other, now extinct archaic hominin varieties in Africa remained unclear.

In a paper published in the Proceedings of the National Academy of Sciences, or PNAS, a team led by Michael Hammer, an associate professor and research scientist with the UA’s Arizona Research Labs, provides evidence that anatomically modern humans were not so unique that they remained separate. (more…)

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Life Scientists Use Novel Technique to Produce Genetic Map for African Americans

UCLA life scientists and colleagues have produced one of the first high-resolution genetic maps for African American populations. A genetic map reveals the precise locations across the genome where DNA from a person’s father and mother have been stitched together through a biological process called “recombination.” This process results in new genetic combinations that are then passed on to the person’s children.

The new map will help disease geneticists working to map genetic diseases in African Americans because it provides a more accurate understanding of recombination rates among that population, said the senior author of the research, John Novembre, a UCLA assistant professor of ecology and evolutionary biology and of bioinformatics. The map could help scientists learn the roots of these diseases and discover genes that play a key role in them. (more…)

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