Tag Archives: artificial membranes

A Shiny New Tool for Imaging Biomolecules

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Berkeley Lab Researchers Embed Artificial Membranes with Billions of Nanoantennas for Enhanced Optical Studies

At the heart of the immune system that protects our bodies from disease and foreign invaders is a vast and complex communications network involving millions of cells, sending and receiving chemical signals that can mean life or death. At the heart of this vast cellular signaling network are interactions between billions of proteins and other biomolecules. These interactions, in turn, are greatly influenced by the spatial patterning of signaling and receptor molecules. The ability to observe signaling spatial patterns in the immune and other cellular systems as they evolve, and to study the impact on molecular interactions and, ultimately, cellular communication, would be a critical tool in the fight against immunological and other disorders that lead to a broad range of health problems including cancer. Such a tool is now at hand. (more…)

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Berkeley Lab Scientists Develop New Tool for the Study of Spatial Patterns in Living Cells

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*Golden Membranes Pave the Way for a Better Understanding of Cancer and the Immune System*

Football has often been called “a game of inches,” but biology is a game of nanometers, where spatial differences of only a few nanometers can determine the fate of a cell – whether it lives or dies, remains normal or turns cancerous. Scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a new and better way to study the impact of spatial patterns on living cells.

Berkeley Lab chemist Jay Groves led a study in which artificial membranes made up of a fluid bilayer of lipid molecules were embedded with fixed arrays of gold nanoparticles to control the spacing of proteins and other cellular molecules placed on the membranes. This provided the researchers with an unprecedented opportunity to study how the spatial patterns of chemical and physical properties on membrane surfaces influence the behavior of cells. (more…)

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