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Solving The Mystery of An Old Drug That May Reduce Cancer Risk

By Guest PostJanuary 19, 2012Health, Scienceanti diabetic drug, anti diabetic function, antioxidant, breast, cancer, cancer risk, carcinogenesis, cellular mutation rate, colon, diabetics, dna damage, gerardo ferbeyre, mcgill university, metformin, michael pollak, mitochondria, nutrient, rates of cancer, reactive oxygen species, reduction in risk, ros, scotland, type ii diabetes, université de montréal, university of montreal

In 2005, news first broke that researchers in Scotland found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-per-cent reduction in risk. How could this anti-diabetic drug reduce the risk of developing cancer and what were the mechanisms involved?

In a paper published today in the journal Cancer Prevention Research, researchers from McGill University and the University of Montreal reported an unexpected finding: they learned that exposure to metformin reduces the cellular mutation rate and the accumulation of DNA damage. It is well known that such mutations are directly involved in carcinogenesis, but lowering cancer risk by inhibiting the mutation rate has never been shown to be feasible. (more…)

Scientists Uncover Mechanism That Regulates Human Pluripotent Stem Cell Metabolism

By Guest PostNovember 16, 2011Scienceadenosine triphosphate, atp, body cells, california institute for regenerative medicine, carbon dioxide, carla koehler, cell differentiation, cell functions, chicken or the egg question, cytoplasm, electron transport chain, energy, energy generation by mitochondria in pluripotent stem cells, glycolysis, glycolytic and biosynthesis pathways, human pluripotent stem cells, inactive mitochondria, jin zhang, kim irwin, mature cells in children and adults, metabolic activities, method of generating energy, michael teitell, mitochondria, oxidative phosphorylation, protein, respiration, stem cells, sugar fermentation, ucp2, uncoupling protein 2, visual appearance

Human pluripotent stem cells, which can develop into any cell type in the body, rely heavily on glycolysis, or sugar fermentation, to drive their metabolic activities.

In contrast, mature cells in children and adults depend more on cell mitochondria to convert sugar and oxygen into carbon dioxide and water during a high energy–producing process called oxidative phosphorylation. (more…)

Researcher Discovers Mitochondria Share an Ancestor with SAR11

By Guest PostJuly 27, 2011Scienceeukaryotic cells, evolutionary event, marine bacteria, mitochondria

Billions of years ago, an astounding evolutionary event occurred: certain bacteria became obliged to live inside other cells, thus starting a chain of events that resulted in what is now the mitochondria, an organelle found in all eukaryotic cells. A recent study by researchers at the University of Hawaiʻi at Mānoa and the Oregon State University (OSU) provides strong evidence that mitochondria share a common evolutionary ancestor with a lineage of marine bacteria known as SAR11, arguably the most abundant group of microorganisms on Earth. (more…)

Tag Archives: mitochondria

Solving The Mystery of An Old Drug That May Reduce Cancer Risk

Scientists Uncover Mechanism That Regulates Human Pluripotent Stem Cell Metabolism

Researcher Discovers Mitochondria Share an Ancestor with SAR11