Scientists are locked in a perpetual race with deadly bacteria, struggling to come up with new drugs as bacteria evolve new defenses. Corey Compton has demonstrated that a strategy focused on how bacteria develop resistance can give drugs — new and old — a leg up. (more…)
Mycobacterium tuberculosis, the bacterium that causes tuberculosis may have an Achilles’ heel: It needs a particular enzyme to survive. Inhibiting that enzyme’s function, researchers have shown, will kill the bacteria, pointing toward a design strategy for new TB drugs.
PROVIDENCE, R.I. [Brown University] — To stay ahead in the race against drug-resistant infections, scientists constantly search for and exploit vulnerabilities in deadly bacteria. Now, researchers from Brown and the Massachusetts Institute of Technology have used a novel compound to exploit an Achilles’ heel in the bacterium that causes tuberculosis. (more…)
