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Organics Probably Formed Easily in Early Solar System

By Guest PostApril 4, 2012Scienceamino acids, amphiphiles, bombard, building blocks, cellular membrane, cometary, computer simulation, DNA, dynamics, fred ciesla, life on earth, meteorite, nasa ames, nucleobases, organic compound, planet, proteins, rna, science express, scott sandford, solar nebula, uchicago, ultraviolet radiation, uv radiation

Complex organic compounds, including many important to life on Earth, were readily produced under conditions that likely prevailed in the primordial solar system. Scientists at the University of Chicago and NASA Ames Research Center came to this conclusion after linking computer simulations to laboratory experiments.

Fred Ciesla, assistant professor in geophysical sciences at UChicago, simulated the dynamics of the solar nebula, the cloud of gas and dust from which the sun and the planets formed. Although every dust particle within the nebula behaved differently, they all experienced the conditions needed for organics to form over a simulated million-year period. (more…)

Yale Study: How Mitochondrial DNA Defects Cause Inherited Deafness

By Guest PostFebruary 21, 2012Scienceapoptosis, cascade, cell, cellular power plants, cellular respiration, cellular structure, chemical modification, disease, dna mutation, energy, enzyme, gene, gerald s shadel, hearing loss, helen dodson, inherited deafness, justin cotney, lei song, methylation, mitochondria, mitochondrial dna mutation, mitochondrial ribosomes, molecular pathway, mouse model, overexpression, programmed cell death, protein, rna, sharen e mccay, timothy e shutt, yale scientist

Yale scientists have discovered the molecular pathway by which maternally inherited deafness appears to occur: Mitochondrial DNA mutations trigger a signaling cascade, resulting in programmed cell death. The study is in the Feb. 17 issue of Cell.

Mitochondria are cellular structures that function as “cellular power plants” because they generate most of the cell’s supply of energy. They contain DNA inherited from one’s mother. Mitochondria determine whether a cell lives or dies via the process of programmed cell death, or apoptosis. (more…)

Altered Gene Tracks RNA Editing in Neurons

By Guest PostDecember 26, 2011Scienceadar, brown university, disease, DNA, engineered gene, epilepsy, errors, fluorescent readout, fruit flies, gene expression, glowing green indicator, jellyfish gene, key enzyme, key step, kyle jay, living organisms, mental retardation, molecular biology, molecular reporter, moth, nervous system, radar, rna, rna repair, robert reenan, rube goldberg, schizophrenia, stop codon, suicidal depression, t a g, t g g, ultraviolet light, yannis a savva

*RNA editing is a key step in gene expression. Scientists at Brown University report in Nature Methods that they have engineered a gene capable of visually displaying the activity of the key enzyme ADAR in living fruit flies.*

PROVIDENCE, R.I. [Brown University] — To track what they can’t see, pilots look to the green glow of the radar screen. Now biologists monitoring gene expression, individual variation, and disease have a glowing green indicator of their own: Brown University biologists have developed a “radar” for tracking ADAR, a crucial enzyme for editing RNA in the nervous system.

The advance gives scientists a way to view when and where ADAR is active in a living animal and how much of it is operating. In experiments in fruit flies described in the journal Nature Methods, the researchers show surprising degrees of individual variation in ADAR’s RNA editing activity in the learning and memory centers of the brains of individual flies. (more…)

DNA Caught Rock ‘n Rollin’

By Guest PostFebruary 6, 2011Sciencedamage, deformations in proteins, DNA, dna molecule, double helix, evgenia nikolova, fingerprints, francis crick, hashim al hashimi, james watson, molecule of life, nmr, nuclear magnetic resonance, rna, rock and roll, rope ladder, spiral staircase structure, Technology

ANN ARBOR, Mich.— DNA, that marvelous, twisty molecule of life, has an alter ego, research at the University of Michigan and the University of California, Irvine reveals.

On rare occasions, its building blocks “rock and roll,” deforming the familiar double helix into a different shape. (more…)

New 3-D Model of RNA ‘Core Domain’ of Enzyme Telomerase May Offer Clues to Cancer, Aging

By Guest PostNovember 6, 2010Health, Scienceaging, cancer, cells, chromosomes, DNA, dna damage, enzyme, helical extension, juli feigon, medicine, nmr, nobel prize, nuclear magnetic resonance, physiology, proteins, pseudoknot, qi zhang, rna, spectroscopy, telomerase, telomeres, virus

A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.

But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.

UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say. (more…)

The Genetics of Self-Incompatibility

By Guest PostNovember 6, 2010Nature, Scienceantigens, female, fertilization, genes, genetic, immune response, inbreeding, male, offspring, organism, petunia, petunia pistil, petunia pollen, plant, pollen, proteins, rna, rna-destroying enzyme, seiji takayama, sexual organs, t-cell receptors, teh-hui kao

*Petunias show that the mechanisms behind inbreeding prevention are similar to immune response*

About the image: The female part of the petunia flower secretes an enzyme that is designed to deter pollen tube growth, thereby preventing fertilization. However, in the cases that the pollen has come from a genetically different plant, the pollen produces its own protein that combats the pistil’s enzyme. With the enzyme out of the way, the pollen tube can keep growing and fertilization can occur. Image credit: Zina Deretsky, National Science Foundation

Inbreeding is a bad strategy for any organism, producing weak and problematic offspring. So imagine the challenge of inbreeding prevention in a plant where male and female sexual organs grow right next to each other! Such is the genetic conundrum faced by the petunia. (more…)

Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers

By Guest PostOctober 12, 2010Science, Technologyalgorithms, bioinformatics, biological web services, biometeorologist, blast, cloud computing, data-driven research, dennis baldocchi, DNA, escience workshop, informatics group, jeremy kolpak, johnson & johnson pharmaceutical research, mbf, microsoft biology foundation, microsoft biology initiative, microsoft research, modisazure-based environmental service, programming-language-neutral bioinformatics toolkit, protein sequences, researchers, rna, Technology, tony hey, windows azure

*Two new technologies are showcased at the eScience Workshop to fuel advancement of data-driven research in healthcare and environmental fields.*

BERKELEY, Calif. — Oct. 12, 2010 — With more than 200 researchers in attendance at the seventh annual eScience Workshop, Microsoft Research showcases two technologies that facilitate data-driven research: the Microsoft Biology Foundation (MBF) and a MODISAzure-based environmental service. (more…)

Too Much of a Good Thing: Human Activities Overload Ecosystems with Nitrogen

By Guest PostOctober 7, 2010Environment, Sciencebacteria, burning of fossil fuels, coastal zones, DNA, ecological damage, eutrophication, fresh waters, humans, microorganisms, national science foundation, nitrogen, nitrogen cycle, nitrogen fertilizers, nitrogen fixation, nitrogen-producing industrial and agricultural activities, paul falkowski, photosynthesize, plants, proteins, rna, robert burnap, Rutgers University, time-honored sustainable practices

*Resulting ecological damage is serious, but could be reduced by wider use of more sustainable, time-honored practices*

Humans are overloading ecosystems with nitrogen through the burning of fossil fuels and an increase in nitrogen-producing industrial and agricultural activities, according to a new study. While nitrogen is an element that is essential to life, it is an environmental scourge at high levels. (more…)

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