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Protein interplay in muscle tied to life span

By Guest PostDecember 1, 2013Health, Scienceactivin equivalent, alzheimer's disease, ana maria hernandez, atg8a, autophagy, brain, brown university biologists, central culprit, chain, dawdle, dfoxo, female reproductive system, fly version, fruit flies, gene, hua bai, human aging biology, insulin producing cells, ipcs, life span, mammalian protein, marc tatar, menstrual cycle, misfolded proteins, molecular event, muscle, muscle fibers, muscle tissue, natural mechanism, ping kang, protein degradation, protein interplay, rolf bodmer

Brown University biologists have uncovered a complicated chain of molecular events that leads from insulin to protein degradation in muscles and significantly diminished life span in fruit flies. The new study in PLoS Genetics, which may have broad implications across species, identifies the fly version of the mammalian protein activin as the central culprit in the process.

PROVIDENCE, R.I. [Brown University] — Fruit flies are notoriously short-lived but scientists interested in the biology of aging in all animals have begun to understand why some fruit flies live longer than others. They have documented a direct association between insulin and life span, for example, and have observed a tradeoff between prolific reproduction and longevity. A new study, which may have broad implications across species, ties those findings more closely together by tracing an insulin signaling cascade through to protein quality control in muscle tissue and shortened life span. (more…)

Shaken, not Stirred: Berkeley Lab Scientists Spy Molecular Maneuvers

By Guest PostOctober 24, 2011Scienceandrew cho, atomic precision, babak sanii, berkeley lab, biomimetic materials, catalyze a reaction, development of peptoids, gloria olivier, james bond, langmuir blodgett trough, lawrence berkeley national laboratory, liquid, membrane for filtration, misfolded proteins, molecules, nanomaterials, nanoscale ropes, nanosheet, neeraja venkateswaran, peptoid nanosheets, peptoids, protein like structures, romas kudirka, ron zuckermann, shake, synthetic polymers, two dimensional nanomaterials

Stir this clear liquid in a glass vial and nothing happens. Shake this liquid, and free-floating sheets of protein-like structures emerge, ready to detect molecules or catalyze a reaction. This isn’t the latest gadget from James Bond’s arsenal—rather, the latest research from the U. S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) scientists unveiling how slim sheets of protein-like structures self-assemble. This “shaken, not stirred” mechanism provides a way to scale up production of these two-dimensional nanosheets for a wide range of applications, such as platforms for sensing, filtration and templating growth of other nanostructures.

“Our findings tell us how to engineer two-dimensional, biomimetic materials with atomic precision in water,” said Ron Zuckermann, Director of the Biological Nanostructures Facility at the Molecular Foundry, a DOE nanoscience user facility at Berkeley Lab. “What’s more, we can produce these materials for specific applications, such as a platform for sensing molecules or a membrane for filtration.” (more…)

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Protein interplay in muscle tied to life span

Shaken, not Stirred: Berkeley Lab Scientists Spy Molecular Maneuvers