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How Silver Turns People Blue

By Guest PostOctober 27, 2012Scienceabsorb, acidic environment, agnes kane, antimicrobial, argyria, base membrane, bioavailable salt, bloodstream, brown researcher, brown university, charged ions, disorder, electron, environmental impact, exposure scenario, frances liu, germs, gi tract, grayish blue, health tonics, jingyu liu, medical treatment, nanoparticle, particle, photochemical reaction, protein, robert hurt, salt ion, silver, silver atom, silver salt, skin, toxic, toxicity, zhongying wang

Ingesting silver — in antimicrobial health tonics or for extensive medical treatments involving silver — can cause argyria, condition in which the skin turns grayish-blue. Brown researchers have discovered how that happens. The process is similar to developing black-and-white photographs, and it’s not just the silver.

PROVIDENCE, R.I. [Brown University] — Researchers from Brown University have shown for the first time how ingesting too much silver can cause argyria, a rare condition in which patients’ skin turns a striking shade of grayish blue.

“It’s the first conceptual model giving the whole picture of how one develops this condition,” said Robert Hurt, professor of engineering at Brown and part of the research team. “What’s interesting here is that the particles someone ingests aren’t the particles that ultimately cause the disorder.” (more…)

Exposed To Phthalates as Fetuses, Female Mice Have Altered Reproductive Lives

By Guest PostMarch 20, 2012Sciencebenjamin moyer, brown university, cell growth, chemical, concern list, corn oil, david orenstein, dehp, doses of phthalates, exposure scenario, female mouse fetuses, health effect, in utero, industrial chemical, mammary glands, mary hixon, mehp, mice, organism, Phthalates, plastics, precancerous lesions, reproductive lifespan, reproductive system, toxicology

Many environmental and public health officials are concerned about the potential health effects of phthalates, which are common chemicals used to make plastics softer and more pliable. In the first study to examine what effect in utero doses of phthalates have on the reproductive system of mice, Brown University toxicologists found that extremely high doses were associated with significant changes, such as a shortened reproductive lifespan and abnormal cell growth in mammary glands.

PROVIDENCE, R.I. [Brown University] — Female mouse fetuses exposed to very high doses of a common industrial chemical that makes plastics more pliable develop significant reproductive alterations and precancerous lesions as they grow up, according to a new toxicology study conducted at Brown University.

The administered doses of MEHP, the chemical that results when animals metabolize the industrial phthalate DEHP, were much higher than any normal environmental exposure that people or animals would encounter, said Mary Hixon, assistant professor of pathology and laboratory medicine (research) in The Warren Alpert Medical School of Brown University and a study co-author. (more…)

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How Silver Turns People Blue

Exposed To Phthalates as Fetuses, Female Mice Have Altered Reproductive Lives