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Compound stymies polyomaviruses in lab

By Guest PostNovember 25, 2013Sciencebiologist walter atwood, bk polyomavirus, brown university, chembridge, chemical compound, compound stymies, cyclizing reaction, daniel carney, daniel dimaio, dhq, dihydroquinazolinone, drug, endoplasmic reticulum, er, hours of infection, immune systems, infection, intracellular protein, jason sello, lab cell cultures, pathogen infection, paul williard, people with hiv, polyomavirus, retro, ricin, sv40 polyomavirus, toxins, trafficking mechanisms, transportation hub, treat polyomaviruses, yale university

There is no approved medicine to treat polyomaviruses, which afflict people with weakened immune systems, but scientists have found that a chemical compound called Retro-2 is able to reduce significantly the infectivity and spread of the viruses in lab cell cultures. Now they are working to improve it.

PROVIDENCE, R.I. [Brown University] — A team of scientists reports that a small-molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened. (more…)

Everest Expedition Suggests Nitric Oxide Benefits for Intensive Care Patients

The latest results from an expedition to Mount Everest that looked at the body’s response to low oxygen levels suggest that drugs or procedures that promote the body’s production of a chemical compound called nitric oxide (NO) could improve the recovery of critically ill patients in intensive care.

Many critically ill patients suffer from a shortage of oxygen (a condition known as ‘hypoxia’), which can be life-threatening. NO is produced by virtually every cell and organ in the body where it serves many important functions including the regulation of blood pressure, learning and memory formation, and protecting us from infectious diseases. (more…)

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Compound stymies polyomaviruses in lab

Everest Expedition Suggests Nitric Oxide Benefits for Intensive Care Patients