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Single mutation gives virus new target

A mutation as minute as swapping just one amino acid can completely change the target that a virus will bind to on a victim cell — potentially shifting what kind of cell and eventually what kind of organism a virus could infect.

PROVIDENCE, R.I. [Brown University] — In a new study published online in the journal PLoS Pathogens, an international team of scientists showed that by swapping a single amino acid they could change the sugar to which the human BK polyomavirus will binds on the surface of cells. The BK polyomavirus lost the ability to bind its usual target sugar and instead “preferred” the same sugar as its cousin SV40 polyomavirus, which is active in monkeys. (more…)

A tangle of talents untangles neurons

By Guest PostJune 10, 2013Sciencebiological phenomenon, brain science, brown university, cell cultures, cristina lopez fagundo, diane hoffman kim, jennifer mitchel, microfabrication facility, mike cohea, nerve cells, neurons, puerto rico, rat neural tissue, schwann cells, semiconductor, substrates, talisha ramchal, tangle of talents, techniques, technological ingenuity, topography, university, yu ting dingle

Brown’s growing programs in brain science and engineering come together in the lab of Diane Hoffman-Kim. In a recent paper, her group employed techniques ranging from semiconductor-style circuit patterning to rat cell culture to optimize the growth of nerve cells for applications such as reconstructive surgery.

PROVIDENCE, R.I. [Brown University] — Two wrongs don’t make a right, they say, but here’s how one tangle can straighten out another.

Diane Hoffman-Kim, associate professor of medicine in the Department of Molecular Pharmacology, Physiology, and Biotechnology, is an affiliate of both Brown’s Center for Biomedical Engineering and the Brown Institute for Brain Science. Every thread of expertise woven through those multidisciplinary titles mattered in the Hoffman-Kim lab’s most recent paper, led by graduate student Cristina Lopez-Fagundo. (more…)

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Single mutation gives virus new target

A tangle of talents untangles neurons