Tag Archives: cancers

Research Suggests HIV Causes Rapid Aging in Key Infection-fighting Cells

In the early years of the AIDS epidemic, being infected with the virus that causes the disease was considered a virtual death sentence. But with the development of antiretroviral therapy, many with HIV are now living much longer. In fact, it is estimated that by 2015, about half of all HIV-positive individuals will be older than 50. 

Yet those over 50 also progress to AIDS faster than adults in their 20s or 30s. And those in the younger age bracket — even those responding well to antiretroviral therapy — still exhibit illnesses and clinical conditions commonly associated with older people, such as certain cancers and liver diseases. For the most part, the reasons for this have remained a mystery.  (more…)

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Discovery of a Mechanism that Controls the Expression of a Protein Involved in Numerous Cancers

Marc Therrien. Image credit: University of Montreal

Researchers at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have identified a new mechanism controlling the transmission of an abnormal signal at the origin of several cancers. In an article published in the journal Cell, Marc Therrien’s team explains the recent discovery of a protein complex that controls the RAS/MAPK signalling pathway, responsible for some of the deadliest cancers, including pancreatic, colon and lung cancers, and melanomas. This regulating mechanism could prove to be a promising therapeutic target for the treatment of these diseases.  The study conducted on the drosophila model organism is to be verified in humans in a forthcoming step. (more…)

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