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A Second Pathway for Antidepressants: Berkeley Lab Reports New Fluorescent Assay Reveals TREK1 Mechanism

By Guest PostFebruary 25, 2011Scienceantidepressant drugs, berkeley lab, c terminal, cell based fluorescent assay, cytoplasm, ehud isacoff, flow of electrical current, fluorescent protein, fluoxetine, gfp, green fluorescent protein, guillaume sandoz, high speed transistors, human brain, ion channels, membrane, molecular gates, neurons, pharmacological agents, plasma membrane, protein, prozac, sarah bell, transmembrane proteins, trek1, trek1 potassium channel

Using a unique and relatively simple cell-based fluorescent assay they developed, scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC), Berkeley have identified a means by which fluoxetine, the active ingredient in Prozac, suppresses the activity of the TREK1 potassium channel. TREK1 activity has been implicated in mood regulation and could be an important target for fluoxetine and other antidepressant drugs. (more…)

Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass

By Guest PostNovember 13, 20102 commentsScienceaging, bradley olwin, cell transplant, chronic, degenerative muscle diseases, green fluorescent protein, leg muscles, mice, muscle function, muscle stem cells, myofibers, satellite cells, stem cells, transplant, ultraviolet light, university of colorado at boulder

A University of Colorado at Boulder-led study shows that specific types of stem cells transplanted into the leg muscles of mice prevented the loss of muscle function and mass that normally occurs with aging, a finding with potential uses in treating humans with chronic, degenerative muscle diseases.

The experiments showed that when young host mice with limb muscle injuries were injected with muscle stem cells from young donor mice, the cells not only repaired the injury within days, they caused the treated muscle to double in mass and sustain itself through the lifetime of the transplanted mice. “This was a very exciting and unexpected result,” said Professor Bradley Olwin of CU-Boulder’s molecular, cellular and developmental biology department, the study’s corresponding author. (more…)

Tag Archives: green fluorescent protein

A Second Pathway for Antidepressants: Berkeley Lab Reports New Fluorescent Assay Reveals TREK1 Mechanism

Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass