Tag Archives: min zhuo

Switch off Enzyme to Control Chronic Pain, say U of T Researchers

*New drug shows promise for treating chronic pain*

A team of researchers at the University of Toronto has developed a new drug targeted at parts of the brain and spinal cord associated with pain perception, which may more effectively control chronic pain caused by nerve injuries.

In a paper published Jan. 12 in the journal Science Translational Medicine, a team led by Professor Min Zhuo of the Department of Physiology and Centre for the Study of Pain, the Canada Research Chair in Pain and Cognition, showed that a new drug called NB001 produced powerful pain-killing effects in mice and in human neuronal cell lines. (more…)

Read More

U of T Researcher Discovers Way to Zip Away Chronic Pain

*Peptide inhibitor called ZIP may be instrumental* 

Research from the University of Toronto suggests that a peptide inhibitor called ZIP could be crucial in zipping away some kinds of chronic pain. 

The new research, led by Professor Min Zhuo of the University of Toronto’s Department of Physiology and published in the current edition of the journal Science, explores the role that the protein kinase M zeta (PKMζ) plays in storing “memories” of pain and therefore enhancing the sensation of pain. Blocking the effect of PKMζ through the use of a selective inhibitor called ζ-pseudosubstrate inhibitory peptide – or ZIP — blocked behavioral sensitization and nerve injury related to chronic pain.  (more…)

Read More