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U of T Researcher Discovers Way to Zip Away Chronic Pain

*Peptide inhibitor called ZIP may be instrumental* 

Research from the University of Toronto suggests that a peptide inhibitor called ZIP could be crucial in zipping away some kinds of chronic pain. 

The new research, led by Professor Min Zhuo of the University of Toronto’s Department of Physiology and published in the current edition of the journal Science, explores the role that the protein kinase M zeta (PKMζ) plays in storing “memories” of pain and therefore enhancing the sensation of pain. Blocking the effect of PKMζ through the use of a selective inhibitor called ζ-pseudosubstrate inhibitory peptide – or ZIP — blocked behavioral sensitization and nerve injury related to chronic pain.  (more…)

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