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Gene Mutation Discovery Sparks Hope For Effective Endometriosis Screening

By Guest PostFebruary 9, 2012Health, Scienceabdominal cavity, cervix, chronic pelvic pain, endometrial growth, endometrial risk, endometriosis, gene mutation, genetic basis, hugh s taylor, infertility, joanne weidhaas, kras gene, kras protein, mutation, olga grechukhina, ovaries, rafaella petracco, school of medicine, shota popkhadze, therapeutic target, uterine tissue, vagina, yale

Researchers at Yale School of Medicine have, for the first time, described the genetic basis of endometriosis, a condition affecting millions of women that is marked by chronic pelvic pain and infertility. The researchers’ discovery of a new gene mutation provides hope for new screening methods.

Published in the Feb. 3 early online issue of EMBO Molecular Medicine, the study explored an inherited mutation located in part of the KRAS gene, which leads to abnormal endometrial growth and endometrial risk. In endometriosis, uterine tissue grows in other parts of the body, such as the abdominal cavity, ovaries, vagina, and cervix. The condition is often hereditary and is found in 5%-15% of women of reproductive age, affecting over 70 million women worldwide. (more…)

Fat Cells in Abdomen Fuel Spread of Ovarian Cancer

By Guest PostNovember 4, 2011Health, Scienceabdominal cavity, breast cancer, cause of cancer deaths in women, energy dense lipids, ernst lengyel, fabp4, fat carrier, fat cells, fatty acid binding protein, fatty tissue, gastric and colon cancers, growth of ovarian cancer, healthy mice, hilary kenny, intestines, kristin nieman, nutrients, omentum, ovarian cancer, ovarian cancer cells, ovarian cancer metastasis, protein, protein signals, stomach, tumor cells, university of chicago

A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a University of Chicago-based research team in the journal Nature Medicine, published online Oct. 30.

Ovarian cancer, the fifth-leading cause of cancer deaths in women, tends to spread within the abdominal cavity as opposed to distant organs. In 80 percent of women, by the time ovarian cancer is diagnosed, it has spread to the pad of fat cells, called the omentum. Often, cancer growth in the omentum exceeds the growth of the original ovarian cancer. (more…)

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Gene Mutation Discovery Sparks Hope For Effective Endometriosis Screening

Fat Cells in Abdomen Fuel Spread of Ovarian Cancer