Berkeley Lab Researchers Develop New Metrics for X-ray and Neutron Analysis of Flexible Macromolecules
A dramatic leap forward in the ability of scientists to study the structural states of macromolecules such as proteins and nanoparticles in solution has been achieved by a pair of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have developed a new set of metrics for analyzing data acquired via small angle scattering (SAS) experiments with X-rays (SAXS) or neutrons (SANS). Among other advantages, this will reduce the time required to collect data by up to 20 times.
“SAS is the only technique that provides a complete snapshot of the thermodynamic state of macromolecules in a single image,” says Robert Rambo, a scientist with Berkeley Lab’s Physical Biosciences Division, who developed the new SAS metrics along with John Tainer of Berkeley Lab’s Life Sciences Division and the Scripps Research Institute. (more…)